BDBM50468877 CHEMBL4286690

SMILES OC(=O)c1ccc(cc1)N(Cc1ccc2ccccc2c1)S(=O)(=O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=NSQFINFAOGRDMM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50468877   

TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50468877(CHEMBL4286690)
Affinity DataIC50: 300nMAssay Description:Inhibition of mPGES-1 isolated from microsomes of interleukin-1 beta-stimulated human A549 cells using PGH2 as substrate preincubated for 15 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50468877(CHEMBL4286690)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 (DE3) using arachidonic acid as substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50468877(CHEMBL4286690)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate assessed as reduction in 5-LO product formation preincubated for 15 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed