BDBM50481119 AZD-2184::CHEMBL570378

SMILES CNc1ccc(cn1)-c1nc2ccc(O)cc2s1

InChI Key InChIKey=FYTAUNFPOYWHBC-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50481119   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481119(AZD-2184 | CHEMBL570378)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brain by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481119(AZD-2184 | CHEMBL570378)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481119(AZD-2184 | CHEMBL570378)
Affinity DataKd:  8.40nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) fibrils after 3 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50481119(AZD-2184 | CHEMBL570378)
Affinity DataIC50:  58nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed