BDBM50490618 Midalcipran::Milnacipran

SMILES CCN(CC)C(=O)C1(CC1CN)c1ccccc1

InChI Key InChIKey=GJJFMKBJSRMPLA-UHFFFAOYSA-N

Data  1 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50490618   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50490618(Midalcipran | Milnacipran)
Affinity DataKi: <3.16E+4nMAssay Description:Displacement of [3H]WIN35428 from human recombinant DAT transfected in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50490618(Midalcipran | Milnacipran)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of human recombinant CYP2D6 by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50490618(Midalcipran | Milnacipran)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50490618(Midalcipran | Milnacipran)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of human recombinant NET expressed in HEK293 cells assessed as inhibition of [3H]NE reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed