BDBM50506056 CHEMBL4554462

SMILES Cc1c(Cc2ccccc2)nc(-c2ccco2)n1-c1c(Cl)cccc1Cl

InChI Key InChIKey=YQPVLABIYDUDBN-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50506056   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506056(CHEMBL4554462)
Affinity DataIC50:  5nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506056(CHEMBL4554462)
Affinity DataIC50:  84nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506056(CHEMBL4554462)
Affinity DataIC50:  160nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB