BDBM50511422 CHEMBL4446338

SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1

InChI Key InChIKey=MJJJRRMQCUUKEO-IZZDOVSWSA-N

Data  3 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50511422   

TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 alpha(Homo sapiens)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50511422(CHEMBL4446338)
Affinity DataIC50:  950nMAssay Description:Inhibition of PI5P4Kalpha (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50511422(CHEMBL4446338)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to human PI5P4IKgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50511422(CHEMBL4446338)
Affinity DataIC50:  40nMAssay Description:Inhibition of N-terminal GST-tagged full length human PIKFYVE (1 to 2098 residues) using PI(3)P and Phosphatidylserine as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 beta(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50511422(CHEMBL4446338)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed