BDBM50515527 CHEMBL4451049

SMILES COc1ccccc1C(N(C1CCCCC1)C(=O)\C=C\C(=O)c1ccc(C)cc1)C(=O)NC1CCCCC1

InChI Key InChIKey=GAIRAQHWWXYQQO-QURGRASLSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50515527   

TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
University Of Belgrade

Curated by ChEMBL
LigandPNGBDBM50515527(CHEMBL4451049)
Affinity DataIC50:  5.12E+4nMAssay Description:Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
University Of Belgrade

Curated by ChEMBL
LigandPNGBDBM50515527(CHEMBL4451049)
Affinity DataIC50:  3.12E+3nMAssay Description:Inhibition of rat TrxR1 using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
University Of Belgrade

Curated by ChEMBL
LigandPNGBDBM50515527(CHEMBL4451049)
Affinity DataIC50:  5.28E+3nMAssay Description:Inhibition of TrxR1 (unknown origin) using DTNB as substrate preincubated for 30 mins in presence of insulin followed by substrate addition by colori...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed