BDBM50521218 CHEMBL4434674

SMILES COc1ncc(cc1NS(C)(=O)=O)-c1cc(-c2ncc(CN3C[C@H](C)O[C@H](C)C3)o2)c2cn[nH]c2c1

InChI Key InChIKey=NLUPPCTVKHDVIQ-UHFFFAOYSA-N

Data  5 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50521218   

LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant human full length P13Kdelta expressed in Sf9 cells assessed as reduction in ATP-dependent phosphorylation by chromatography...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of PI3KD (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataKi:  0.0794nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HT...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataKi:  0.0794nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed