BDBM50531786 CHEMBL4573445::US11530198, Example 74
SMILES Nc1ncc(N2CCN(CC2)c2cccc(c2)-c2cncnc2)c(N)n1
InChI Key InChIKey=JYHQPYJPVMGKIX-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50531786
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed by substrate and...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals
Curated by ChEMBL
Vyera Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of Toxoplasma gondii DHFR-TS expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals
Curated by ChEMBL
Vyera Pharmaceuticals
Curated by ChEMBL