BDBM50542241 E127::ERYTHROSINE::US20230364057, Compound 253

SMILES Oc1c(I)cc2c(Oc3c(I)c(O)c(I)cc3C22OC(=O)c3ccccc23)c1I

InChI Key InChIKey=OALHHIHQOFIMEF-UHFFFAOYSA-N

Data  2 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50542241   

TargetNonstructural protein 3(Zika virus)
Australian National University

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of Zika virus NS2B-NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 3(Zika virus)
Australian National University

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataEC50:  600nMAssay Description:Inhibition of Zika virus NS2B-NS3 protease by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase inhibitor()
The Florida International University Board Of Trustees

US Patent
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataIC50:  3.13E+3nMAssay Description:SDFQ HTS primary assay using pAB1_FL905 was performed in 2 µL of (1 xDNA gyrase buffer: 20 mM Tris-Acetate pH 7.9, 50 mM KAc, 10 mM MgCl2, 2 mM DTT, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFlavin reductase (NADPH)(Homo sapiens)
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataKd:  158nMAssay Description:Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlavin reductase (NADPH)(Homo sapiens)
Korea Basic Science Institute

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataKd:  160nMAssay Description:Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed