BDBM50544430 CHEMBL4647377::US11192850, Entry 4j

SMILES OC(=O)C(=O)Nc1ccc(cc1)C#Cc1cccc(c1)C(F)(F)F

InChI Key InChIKey=KJCWXIZZPNBYHI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50544430   

TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544430(CHEMBL4647377 | US11192850, Entry 4j)
Affinity DataIC50:  53nMAssay Description:Inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate measured after 30 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544430(CHEMBL4647377 | US11192850, Entry 4j)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of SHP2 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544430(CHEMBL4647377 | US11192850, Entry 4j)
Affinity DataIC50:  2.95E+4nMAssay Description:Inhibition of PTP1B (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544430(CHEMBL4647377 | US11192850, Entry 4j)
Affinity DataIC50:  2.95E+4nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTriple specificity protein phosphatase PtpB()
Purdue Research Foundation

US Patent
LigandPNGBDBM50544430(CHEMBL4647377 | US11192850, Entry 4j)
Affinity DataIC50:  53nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Purdue Research Foundation

US Patent
LigandPNGBDBM50544430(CHEMBL4647377 | US11192850, Entry 4j)
Affinity DataIC50: >5.00E+4nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Purdue Research Foundation

US Patent
LigandPNGBDBM50544430(CHEMBL4647377 | US11192850, Entry 4j)
Affinity DataIC50: >5.00E+4nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Purdue Research Foundation

US Patent
LigandPNGBDBM50544430(CHEMBL4647377 | US11192850, Entry 4j)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed