BDBM50547979 CHEMBL4752754

SMILES Cc1nn(C)cc1-c1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3ccccc3F)c2F)c2ncnc(N)c2c1

InChI Key InChIKey=SLZQHMNLJFHHQH-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50547979   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma

Curated by ChEMBL
LigandPNGBDBM50547979(CHEMBL4752754)
Affinity DataIC50:  44nMAssay Description:Inhibition of IRE1alpha (unknown origin) assessed as XBP-1 slicing luciferase activity incubated for 1 hr followed by stimulation with thapsigargin m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma

Curated by ChEMBL
LigandPNGBDBM50547979(CHEMBL4752754)
Affinity DataIC50:  40nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB