BDBM50553944 CHEMBL4780624

SMILES CCOC(=O)[C@@H](Cc1ncccn1)NC(=O)Nc1c2CCCc2cc2CCCc12

InChI Key InChIKey=DGKQGJVFBMUMLC-GOSISDBHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50553944   

TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Nodthera

Curated by ChEMBL
LigandPNGBDBM50553944(CHEMBL4780624)
Affinity DataIC50:  36nMAssay Description:Inhibition of NLRP3 in human PBMC cells assessed as inhibition of LPS and ATP-induced IL-1beta productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Nodthera

Curated by ChEMBL
LigandPNGBDBM50553944(CHEMBL4780624)
Affinity DataIC50:  33nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in nigercin-induced ASC speck formation measuring green fluorescent protein aggregatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Nodthera

Curated by ChEMBL
LigandPNGBDBM50553944(CHEMBL4780624)
Affinity DataIC50:  160nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as inhibition of LPS and ATP-induced IL-1beta productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed