BDBM50557775 CHEMBL4758903
SMILES Cc1cc(F)c(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1-c1ccc2c(cnn(C)c2=O)c1
InChI Key InChIKey=HNPPSQOOISWCRJ-UHFFFAOYSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50557775
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKi: <0.0500nMAssay Description:Inhibition of CRAF Y340D/Y341D mutant (unknown origin) assessed as using inactive phosphorylated MAP2K1 substrate preincubated for 30 mins measured a...More data for this Ligand-Target Pair
Affinity DataKi: <0.0800nMAssay Description:Inhibition of BRAF (unknown origin) (416 to 766) assessed as using inactive phosphorylated MAP2K1 substrate preincubated for 30 mins measured after 9...More data for this Ligand-Target Pair