BDBM50563422 CHEMBL4760108

SMILES OC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1

InChI Key InChIKey=SEXCSTOTDUMWPC-UHFFFAOYSA-N

Data  6 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50563422   

TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50:  5.01E+3nMAssay Description:Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50:  103nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins before CCL2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins before CCL2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50:  3.98E+3nMAssay Description:Antagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50:  79nMAssay Description:Antagonist activity at human CCR2 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataIC50:  87nMAssay Description:Antagonist activity at human CCR2 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed