BDBM50567047 CHEMBL4848254

SMILES CN(C)c1nccc(n1)-c1cnn2ncccc12

InChI Key InChIKey=IFLBFWBMAWIBBZ-UHFFFAOYSA-N

Data  3 IC50  14 Kd  1 Koff

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50567047   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataIC50:  76nMAssay Description:Displacement of Kinase tracer 236 from biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by TR-FRET...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataIC50:  590nMAssay Description:Inhibition of human DYRK1A-mediated tau phosphorylation expressed in HEK293 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  85nMAssay Description:Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured up to 5 ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  3nMAssay Description:Binding affinity to wild-type human partial length DYRK1A (H129 to S509 residues) expressed in mammalian expression system measured after 1 hr by com...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  15nMAssay Description:Binding affinity to wild-type human partial length HASPIN (I452 to K798 residues) expressed in mammalian expression system measured after 1 hr by com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  56nMAssay Description:Binding affinity to wild-type human full length DYRK1B (M1 to S629 residues) expressed in bacterial expression system measured after 1 hr by competit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  61nMAssay Description:Binding affinity to wild-type human partial length CLK4 (R135 to K481 residues) expressed in bacterial expression system measured after 1 hr by compe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  70nMAssay Description:Binding affinity to wild-type human full length CLK1 (M1 to I484 residues) expressed in bacterial expression system measured after 1 hr by competitiv...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  220nMAssay Description:Binding affinity to wild-type human partial length CLK2 (D144 to R498 residues) expressed in bacterial expression system measured after 1 hr by compe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  360nMAssay Description:Binding affinity to wild-type human full length DYRK2 (M1 to S528 residues) expressed in mammalian expression system measured after 1 hr by competiti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHomeodomain-interacting protein kinase 2(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to wild-type human partial length HIPK2 (M153 to S564 residues) expressed in mammalian expression system measured after 1 hr by comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity to wild-type human partial length MKNK2 (G63 to S388 residues) expressed in mammalian expression system measured after 1 hr by compe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type 1B(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to wild-type human partial length CAMK1B (W9 to A311 residues) expressed in mammalian expression system measured after 1 hr by compe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity to wild-type human partial length JAK3 JH1 catalytic domain (I781 to S1124 residues) expressed in mammalian expression system measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSTE20/SPS1-related proline-alanine-rich protein kinase(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to wild-type human partial length STK39 (P43 to I357 residues) expressed in mammalian expression system measured after 1 hr by compe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK2(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to wild-type human partial length WNK2 (V47 to D482 residues) expressed in mammalian expression system measured after 1 hr by compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataIC50:  220nMAssay Description:Inhibition of full length GST-tagged human DYRK1A phosphorylation expressed in baculovirus expression system in presence of [gamma-33P]ATP by radiome...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM50567047(CHEMBL4848254)
Affinity DataKon:  0.240M-1s-1Assay Description:Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation rate constant measured up ...More data for this Ligand-Target Pair