BDBM50572749 CHEMBL4854710

SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1

InChI Key InChIKey=YFAJNNAOUUTCEC-UHFFFAOYSA-N

Data  10 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50572749   

TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged NSD2 CD (941 to 1240 residues) expressed in Escherichia coli using SAM as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of NSD2 E1009K mutant (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA ...More data for this Ligand-Target Pair
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TargetHistone-lysine N-methyltransferase SETD2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SETD2 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PRMT5 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHistone-lysine N-methyltransferase 2A(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MLLI (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by HTRF metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHistone-lysine N-methyltransferase 2B(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MLL4 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by HTRF metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of DOT1L (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PRMT4 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50572749(CHEMBL4854710)
Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16N2O2S.ClH/c18-16-10-4-9-15-14(16)8-5-11-17(15)22(20,21)19-12-13-6-2-1-3-7-13;/h1-11,19H,12,18H2;1H
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by HTRF metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed