BDBM50582730 CHEMBL5087055

SMILES Cc1c(cnn1[C@@H]2CCOC2)Nc3nc(c4c(c(n(c4n3)C)N5CCC[C@H]5C)C#N)N

InChI Key InChIKey=QSDVZPULRUJSBC-UHFFFAOYSA-N

Data  8 IC50  4 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50582730   

LigandChemical structure of BindingDB Monomer ID 50582730BDBM50582730(CHEMBL5087055)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to human LRRK2 WT expressed in mammalian system assessed as dissociation constant measured at 1 uM by DiscoveRx KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50582730BDBM50582730(CHEMBL5087055)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to human LRRK2 (H970/E2527) G2019S mutant expressed in mammalian system assessed as dissociation constant measured at 1 uM by Discov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582730BDBM50582730(CHEMBL5087055)
Affinity DataKd:  470nMAssay Description:Binding affinity to human FLT3 ITD, D835V (V592/Y969) mutant expressed in mammalian system assessed as dissociation constant measured at 1 uM by Disc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582730BDBM50582730(CHEMBL5087055)
Affinity DataKd:  850nMAssay Description:Binding affinity to human PIK4CB (M1/M828) WT expressed in mammalian system assessed as dissociation constant measured at 1 uM by DiscoveRx KINOMEsca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed