BDBM50583928 CHEMBL5080711

SMILES CC1(C)CNC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2c(c(ccc12)C#N)P(C)(C)=O)C(F)(F)F

InChI Key InChIKey=DQFXKZPDQHUJLY-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50583928   

TargetCyclin-dependent kinase 12(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583928BDBM50583928(CHEMBL5080711)
Affinity DataIC50: 156nMAssay Description:Inhibition of CDK12/cyclin K (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583928BDBM50583928(CHEMBL5080711)
Affinity DataIC50: 572nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583928BDBM50583928(CHEMBL5080711)
Affinity DataIC50: 771nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed