BDBM50585046 CHEMBL5086263

SMILES CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2

InChI Key InChIKey=YVQOYBIBWBAHKH-UHFFFAOYSA-N

Data  32 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50585046   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 3nMAssay Description:Inhibition of DYRK1A (unknown origin) at 1 uM by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 3nMAssay Description:Inhibition of DYRK1A (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 5nMAssay Description:Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 5nMAssay Description:Inhibition of DYRK1B (unknown origin) at 1 uM by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 37nMAssay Description:Inhibition of RSK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-2(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 61nMAssay Description:Inhibition of RSK3 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 80nMAssay Description:Inhibition of RSK2 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 82nMAssay Description:Inhibition of RSK1 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 90nMAssay Description:Inhibition of FAK (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMisshapen-like kinase 1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 115nMAssay Description:Inhibition of MINK1 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 132nMAssay Description:Inhibition of MEK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 182nMAssay Description:Inhibition of RSK2 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 210nMAssay Description:Inhibition of FAK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 690nMAssay Description:Inhibition of SGK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of JNK2 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of JNK1 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 19(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of YSK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK3 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed