BDBM516028 US11053238, Compound 1a::US11053238, Compound 1b

SMILES CN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCCC5(CC5)n4c3c2)nc1

InChI Key InChIKey=PVALJOGFUQEXQH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 516028   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516028(US11053238, Compound 1a | US11053238, Compound 1b)
Affinity DataIC50:  3nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516028(US11053238, Compound 1a | US11053238, Compound 1b)
Affinity DataIC50:  23nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516028(US11053238, Compound 1a | US11053238, Compound 1b)
Affinity DataIC50:  1.70nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516028(US11053238, Compound 1a | US11053238, Compound 1b)
Affinity DataIC50:  121nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent