BDBM521195 4-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxyphenyl]-3- (1H-indol-5-yl)- 2H- thiochromen-7- ol::US11149031, Example 19

SMILES Oc1ccc2C(=C(CSc2c1)c1ccc2[nH]ccc2c1)c1ccc(O[C@H]2CCN(CCCF)C2)cc1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521195   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandPNGBDBM521195(4-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]o...)
Affinity DataIC50:  7nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM521195(4-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]o...)
Affinity DataIC50:  11nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandPNGBDBM521195(4-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]o...)
Affinity DataIC50:  23nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent