BDBM521415 6-(2,4- dichlorophenyl)- 5-[6-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3-yl]oxy- 3-pyridyl]-8,9- dihydro-7H- benzo[7]annulen- 2-ol::US11149031, Example 239

SMILES Oc1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)nc2)c1

InChI Key InChIKey=LDHPUKITBCOGKO-QHCPKHFHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521415   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandPNGBDBM521415(6-(2,4- dichlorophenyl)- 5-[6-[(3S)-1-(3- fluoropr...)
Affinity DataIC50:  13nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM521415(6-(2,4- dichlorophenyl)- 5-[6-[(3S)-1-(3- fluoropr...)
Affinity DataIC50:  9nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandPNGBDBM521415(6-(2,4- dichlorophenyl)- 5-[6-[(3S)-1-(3- fluoropr...)
Affinity DataIC50:  13nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent