BDBM522041 N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- benzothiazin-7-yl]-1-[(1- methyltriazol-4- yl)methyl]pyrazol-4- yl]pyrazolo[1,5-a]pyrimidine- 3-carboxamide::US11155557, Example 131

SMILES Cn1cc(Cn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc3SCCNc3cc2OC(F)F)nn1

InChI Key InChIKey=LIWWZPGNFLTTAB-UHFFFAOYSA-N

Data  2 KI

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522041   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522041(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES Cn1cc(Cn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc3SCCNc3cc2OC(F)F)nn1
Show InChI InChI=1S/C23H20F2N10O2S/c1-33-10-13(30-32-33)11-34-12-17(29-22(36)15-9-28-35-5-2-3-27-21(15)35)20(31-34)14-7-19-16(26-4-6-38-19)8-18(14)37-23(24)25/h2-3,5,7-10,12,23,26H,4,6,11H2,1H3,(H,29,36)
Affinity DataKi:  0.0800nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522041(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES Cn1cc(Cn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc3SCCNc3cc2OC(F)F)nn1
Show InChI InChI=1S/C23H20F2N10O2S/c1-33-10-13(30-32-33)11-34-12-17(29-22(36)15-9-28-35-5-2-3-27-21(15)35)20(31-34)14-7-19-16(26-4-6-38-19)8-18(14)37-23(24)25/h2-3,5,7-10,12,23,26H,4,6,11H2,1H3,(H,29,36)
Affinity DataKi:  0.120nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid