BDBM522051 N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- benzothiazin-7-yl]-1-(2- oxotetrahydrofuran-3- yl)pyrazol-4-yl]pyrazolo[1,5- a]pyrimidine-3-carboxamide::US11155557, Example 141::US11155557, Example 142

SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCOC1=O

InChI Key InChIKey=HKZKUYDLAQQSJQ-UHFFFAOYSA-N

Data  4 KI

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 522051   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522051(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCOC1=O
Show InChI InChI=1S/C23H19F2N7O4S/c24-23(25)36-17-9-14-18(37-7-4-26-14)8-12(17)19-15(11-32(30-19)16-2-6-35-22(16)34)29-21(33)13-10-28-31-5-1-3-27-20(13)31/h1,3,5,8-11,16,23,26H,2,4,6-7H2,(H,29,33)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522051(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCOC1=O
Show InChI InChI=1S/C23H19F2N7O4S/c24-23(25)36-17-9-14-18(37-7-4-26-14)8-12(17)19-15(11-32(30-19)16-2-6-35-22(16)34)29-21(33)13-10-28-31-5-1-3-27-20(13)31/h1,3,5,8-11,16,23,26H,2,4,6-7H2,(H,29,33)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522051(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCOC1=O
Show InChI InChI=1S/C23H19F2N7O4S/c24-23(25)36-17-9-14-18(37-7-4-26-14)8-12(17)19-15(11-32(30-19)16-2-6-35-22(16)34)29-21(33)13-10-28-31-5-1-3-27-20(13)31/h1,3,5,8-11,16,23,26H,2,4,6-7H2,(H,29,33)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522051(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCOC1=O
Show InChI InChI=1S/C23H19F2N7O4S/c24-23(25)36-17-9-14-18(37-7-4-26-14)8-12(17)19-15(11-32(30-19)16-2-6-35-22(16)34)29-21(33)13-10-28-31-5-1-3-27-20(13)31/h1,3,5,8-11,16,23,26H,2,4,6-7H2,(H,29,33)
Affinity DataKi:  0.170nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid