BDBM531296 US11208399, Example 53

SMILES CN1CCC[C@H](C1)Nc1cc(c(nn1)-c1ccc(cc1O)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=BGHBRFNKKNQTOB-LLVKDONJSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 531296   

TargetTumor necrosis factor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM531296(US11208399, Example 53)
Affinity DataIC50: >3.30E+4nMAssay Description:Monocytic THP-1 cells were maintained according to providers' instructions in RPMI media as described above. Undifferentiated cells were plated a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM531296(US11208399, Example 53)
Affinity DataIC50:  0.400nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent