BDBM535249 US11236047, Example 83::US11236047, Example 84::US20230338337, Example 83

SMILES CS(=O)(=O)c1cc(Cl)ccc1CN1C(=O)c2cc(cc(F)c2[C@]1(OCC1(CO)CC1)c1ccc(Cl)cc1)C(O)C1CCOCC1

InChI Key InChIKey=IRIZYNABKNVLML-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 535249   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535249(US11236047, Example 84 | US11236047, Example 83 | ...)
Affinity DataIC50: 1nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535249(US11236047, Example 84 | US11236047, Example 83 | ...)
Affinity DataIC50: 22nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535249(US11236047, Example 84 | US11236047, Example 83 | ...)
Affinity DataIC50: 1nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In DepthDetails
US Patent