BDBM535418 US11236047, Example 278::US11236047, Example 279::US20230338337, Compound 278

SMILES CN1CCN(CC(C)(O)c2cc3C(=O)N(Cc4ccc(cn4)C#N)[C@](OCC4(CC4)C#N)(c3c(F)c2)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=OFUBYOJVTHCLBN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 535418   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535418(US11236047, Example 278 | US11236047, Example 279 ...)
Affinity DataIC50: 0.970nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535418(US11236047, Example 278 | US11236047, Example 279 ...)
Affinity DataIC50: 3.40nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535418(US11236047, Example 278 | US11236047, Example 279 ...)
Affinity DataIC50: 0.970nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535418(US11236047, Example 278 | US11236047, Example 279 ...)
Affinity DataIC50: 3.40nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In DepthDetails
US Patent