BDBM535451 (3R)-3-(4-Chlorophenyl)-2-[(1R)-1-(5- chloropyridin-2-yl)-2-hydroxyethyl]-4- fluoro-3-{[1- (hydroxymethyl)cyclopropyl]methoxy}- 6-(2-hydroxypropan-2-yl)-2,3- dihydro-1H-isoindol-1-one::US11236047, Example 418::US20230338337, Compound 418

SMILES CC(C)(O)c1cc2C(=O)N([C@@H](CO)c3ccc(Cl)cn3)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=OUIQFUHIJYJICV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535451   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535451((3R)-3-(4-Chlorophenyl)-2-[(1R)-1-(5- chloropyridi...)
Affinity DataIC50: 0.810nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535451((3R)-3-(4-Chlorophenyl)-2-[(1R)-1-(5- chloropyridi...)
Affinity DataIC50: 0.810nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In DepthDetails
US Patent