BDBM535734 6-{[(1R)-1-(4-Chlorophenyl)-5-(1- cyclopropyl-1-hydroxyethyl)-7-fluoro- 1-{[1- (hydroxymethyl)cyclopropyl]methoxy}- 3-oxo-2,3-dihydro-1H-isoindol-2- yl]methyl}pyridine-3-carbonitrile::US11236047, Example 415::US20230338337, Compound 415

SMILES CC(O)(C1CC1)c1cc2C(=O)N(Cc3ccc(cn3)C#N)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=KFTDOSOUWLTHRI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535734   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535734(6-{[(1R)-1-(4-Chlorophenyl)-5-(1- cyclopropyl-1-hy...)
Affinity DataIC50: 0.840nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535734(6-{[(1R)-1-(4-Chlorophenyl)-5-(1- cyclopropyl-1-hy...)
Affinity DataIC50: 0.840nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In DepthDetails
US Patent