BDBM535794 (3R)-3-(4-chlorophenyl)-2-[(5- chloropyrimidin-2-yl)methyl]-4-fluoro- 6-[(1S)-1-hydroxy-1-(1- methylpiperidin-4-yl)propyl]-3-(2- hydroxyethoxy)-2,3-dihydro-1H- isoindol-1-one::US11236047, Example 559::US20230338337, Compound 559

SMILES CC[C@](O)(C1CCN(C)CC1)c1cc2C(=O)N(Cc3ncc(Cl)cn3)[C@](OCCO)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=MTVISPOCUBWYQU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535794   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535794((3R)-3-(4-chlorophenyl)-2-[(5- chloropyrimidin-2-y...)
Affinity DataIC50: 0.620nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535794((3R)-3-(4-chlorophenyl)-2-[(5- chloropyrimidin-2-y...)
Affinity DataIC50: 0.620nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In DepthDetails
US Patent