BDBM545418 US11286268, Compound 908

SMILES Cc1cc(-c2cc(Cl)ccc2C#CCn2c(C)nc3cc(c(-c4ccncn4)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1

InChI Key InChIKey=NPQZGIZYKNNCRT-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545418   

TargetEukaryotic translation initiation factor 4E-binding protein 1(Homo sapiens (Human))
eFFECTOR Therapeutics, Inc.

US Patent
LigandPNGBDBM545418(US11286268, Compound 908)
Show SMILES Cc1cc(-c2cc(Cl)ccc2C#CCn2c(C)nc3cc(c(-c4ccncn4)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C33H18ClF3N6O3S/c1-16-10-21(30-29(41-16)23(14-47-30)32(45)46)20-11-19(34)6-5-18(20)4-3-9-43-17(2)42-26-12-24(33(35,36)37)27(25-7-8-39-15-40-25)22(13-38)28(26)31(43)44/h5-8,10-12,14-15H,9H2,1-2H3,(H,45,46)
Affinity DataIC50: 3.26nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid