BDBM545471 US11286268, Compound 962

SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(Nc4cncc(F)c4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1

InChI Key InChIKey=WANYWEPVLVGYAU-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545471   

TargetEukaryotic translation initiation factor 4E-binding protein 1(Homo sapiens (Human))
eFFECTOR Therapeutics, Inc.

US Patent
LigandPNGBDBM545471(US11286268, Compound 962)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(Nc4cncc(F)c4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H21Cl2FN6O4S/c1-15-7-21(30-29(38-15)23(14-46-30)32(43)44)20-8-17(33)3-4-26(20)45-6-5-41-16(2)39-25-10-24(34)28(22(11-36)27(25)31(41)42)40-19-9-18(35)12-37-13-19/h3-4,7-10,12-14,40H,5-6H2,1-2H3,(H,43,44)
Affinity DataIC50: 3.15nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid