BDBM548295 WO2022093820, Compound 63::WO2022093820, Compound 66

SMILES CC[C@@H](C)C[C@@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C

InChI Key InChIKey=CCCFGCDKFZCHBI-JHJVBQTASA-N

Data  2 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 548295   

TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548295(WO2022093820, Compound 63 | WO2022093820, Compound...)
Show SMILES CC[C@@H](C)C[C@@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C16H26N4O2/c1-4-11(2)7-13-9-17-16(21)14-8-15(18-20(13)14)19-5-6-22-10-12(19)3/h8,11-13H,4-7,9-10H2,1-3H3,(H,17,21)/t11-,12-,13-/m1/s1
Affinity DataIC50: 171nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548295(WO2022093820, Compound 63 | WO2022093820, Compound...)
Show SMILES CC[C@@H](C)C[C@@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C16H26N4O2/c1-4-11(2)7-13-9-17-16(21)14-8-15(18-20(13)14)19-5-6-22-10-12(19)3/h8,11-13H,4-7,9-10H2,1-3H3,(H,17,21)/t11-,12-,13-/m1/s1
Affinity DataIC50: 4.53E+4nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed