BDBM548446 WO2022093881, Ex-5.17

SMILES Clc1cc2cnc(NC(=O)[C@@H]3C[C@H]3c3cncnc3)cc2cc1N1CCC(CC1)C#N

InChI Key InChIKey=KVHYYBFHPMONCA-RBUKOAKNSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 548446   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548446(WO2022093881, Ex-5.17)
Show SMILES Clc1cc2cnc(NC(=O)[C@@H]3C[C@H]3c3cncnc3)cc2cc1N1CCC(CC1)C#N
Show InChI InChI=1S/C23H21ClN6O/c24-20-5-16-12-28-22(29-23(31)19-8-18(19)17-10-26-13-27-11-17)7-15(16)6-21(20)30-3-1-14(9-25)2-4-30/h5-7,10-14,18-19H,1-4,8H2,(H,28,29,31)/t18-,19+/m0/s1
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed