BDBM548491 WO2022093881, Ex-9.21

SMILES Cc1cc2cnc(NC(=O)C3CC3c3ccccn3)cc2cc1N1CCN(CC1)C1(C)CCOC1

InChI Key InChIKey=HOGLVIBAZDRBME-UHFFFAOYSA-N

Data  1 IC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 548491   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548491(WO2022093881, Ex-9.21)
Show SMILES Cc1cc2cnc(NC(=O)C3CC3c3ccccn3)cc2cc1N1CCN(CC1)C1(C)CCOC1
Show InChI InChI=1S/C28H33N5O2/c1-19-13-21-17-30-26(31-27(34)23-16-22(23)24-5-3-4-7-29-24)15-20(21)14-25(19)32-8-10-33(11-9-32)28(2)6-12-35-18-28/h3-5,7,13-15,17,22-23H,6,8-12,16,18H2,1-2H3,(H,30,31,34)
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid