BDBM552977 4-fluoro-N-[4-fluoro-5- (2-morpholin-4- ylpyrimidin-5-yl)-2- [(3R,5S)-3,4,5- trimethylpiperazin-1- yl]phenyl]-3,5- dimethylbenzamide::US11319299, Example 28

SMILES C[C@H]1CN(C[C@@H](C)N1C)c1cc(F)c(cc1NC(=O)c1cc(C)c(F)c(C)c1)-c1cnc(nc1)N1CCOCC1

InChI Key InChIKey=HZHCCOARFZTFNJ-OYRHEFFESA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552977   

TargetWD repeat-containing protein 5(Homo sapiens (Human))
Propellon Therapeutics

US Patent
LigandPNGBDBM552977(4-fluoro-N-[4-fluoro-5- (2-morpholin-4- ylpyrimidi...)
Affinity DataKd:  1.5nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMLL1-WRAD2 complex(Homo sapiens (Human))
Propellon Therapeutics

US Patent
LigandPNGBDBM552977(4-fluoro-N-[4-fluoro-5- (2-morpholin-4- ylpyrimidi...)
Affinity DataIC50:  2.74E+3nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent