BDBM453318 BDBM553824::US10730826, Compound 18a

SMILES NCCCCC(NC(=O)C1CCCC1)C(=O)COC(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=JMYIBZJMKVECHO-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 453318   

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50:  0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin K(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin B(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin F(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin L2(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50:  0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50:  0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin K(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin B(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin F(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCathepsin L2(Homo sapiens (Human))
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50:  0.5nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent