BDBM453357 BDBM553861::US10730826, Compound 51a

SMILES NCCCCC(NC(=O)c1cccc(c1)-n1cc(CNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)nn1)C(=O)COc1c(F)cccc1F

InChI Key InChIKey=HZNKXLPJHVXVJC-PNVGJHFQSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 453357   

TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453357(BDBM553861 | US10730826, Compound 51a)
Affinity DataIC50:  0.440nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453357(BDBM553861 | US10730826, Compound 51a)
Affinity DataIC50:  0.400nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetLys-gingipain(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453357(BDBM553861 | US10730826, Compound 51a)
Affinity DataIC50:  0.440nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain (Kgp) were measured in a fluorogenic assay similar t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetLys-gingipain W83(Porphyromonas gingivalis)
Cortexyme

US Patent
LigandPNGBDBM453357(BDBM553861 | US10730826, Compound 51a)
Affinity DataIC50:  0.400nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent