BDBM558875 US11370770, Compound 6z

SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F

InChI Key InChIKey=CHYJUWDXSCFHON-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 558875   

TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50:  720nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50:  360nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50:  100nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50:  1.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50:  6.90E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50: >2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50:  350nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 6(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50:  8.80E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50: >2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent