BDBM572570 1-[4-(4-Chloro-benzenesulfonyl)-phenyl]-3-(1H-pyrazol-4-ylmethyl)-urea::BDBM50569539::US11452717, Example 310

SMILES Clc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)NCC2=CN[H]=C2)cc1

InChI Key InChIKey=ZWNOYZNCOLPPJM-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 572570   

TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM572570(1-[4-(4-Chloro-benzenesulfonyl)-phenyl]-3-(1H-pyra...)
Affinity DataEC50: <100nMAssay Description:NAMPT reaction was performed in 50 mM HEPES, pH 7.5, containing 5 mM MgCl2, 0.1% Prionex, 0.005% Tween 20, and 1 mM TCEP at room temperature in Grein...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM572570(1-[4-(4-Chloro-benzenesulfonyl)-phenyl]-3-(1H-pyra...)
Affinity DataEC50:  23nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed