BDBM5829 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-{4-[methyl({2-[(4-sulfamoylphenyl)amino]pyrimidin-4-yl})amino]phenyl}urea::D3RKN_41::urea deriv. 20

SMILES CN(c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1)c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1

InChI Key InChIKey=YJFKREHADGLMHG-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5829   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM5829(1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-{4-[methy...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM5829(1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-{4-[methy...)
Affinity DataKd:  3.00E+3nMAssay Description:D3R2023More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM5829(1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-{4-[methy...)
Affinity DataKd:  110nMAssay Description:D3R2022More data for this Ligand-Target Pair
In DepthDetails PubMed