BDBM60973 (2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-propanol;hydrochloride::(2R)-1-(isopropylamino)-3-(1-naphthoxy)propan-2-ol;hydrochloride::(2R)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;hydrochloride::(R)-(+)-Propranolol hydrochloride::MLS001333595::SMR000875288::cid_66366

SMILES CC(C)NC[C@@H](O)COc1cccc2ccccc12

InChI Key InChIKey=AQHHHDLHHXJYJD-CQSZACIVSA-N

Data  1 KI  1 IC50  2 Kd  1 EC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 60973   

TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universit£ degli Studi di Perugia

Curated by ChEMBL
LigandPNGBDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)
Show SMILES CC(C)NC[C@@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m1/s1
Affinity DataKi:  1.45E+4nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytesMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)
Show SMILES CC(C)NC[C@@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m1/s1
Affinity DataKd:  0.891nMAssay Description:Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)
Show SMILES CC(C)NC[C@@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m1/s1
Affinity DataEC50:  4.00E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)
Show SMILES CC(C)NC[C@@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m1/s1
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)
Show SMILES CC(C)NC[C@@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m1/s1
Affinity DataKd:  0.890nMAssay Description:Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)More data for this Ligand-Target Pair