BDBM6348 2-Aminoquinazoline 27::8-cyclopentyl-2-{[3-fluoro-4-(piperazin-1-yl)phenyl]amino}quinazolin-7-ol

SMILES Oc1ccc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc2c1C1CCCC1

InChI Key InChIKey=RWHWILFMZJUQKK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6348   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Naeja Pharmaceutical

LigandPNGBDBM6348(2-Aminoquinazoline 27 | 8-cyclopentyl-2-{[3-fluoro...)
Affinity DataIC50:  761nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Naeja Pharmaceutical

LigandPNGBDBM6348(2-Aminoquinazoline 27 | 8-cyclopentyl-2-{[3-fluoro...)
Affinity DataIC50:  1nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Naeja Pharmaceutical

LigandPNGBDBM6348(2-Aminoquinazoline 27 | 8-cyclopentyl-2-{[3-fluoro...)
Affinity DataIC50:  270nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Naeja Pharmaceutical

LigandPNGBDBM6348(2-Aminoquinazoline 27 | 8-cyclopentyl-2-{[3-fluoro...)
Affinity DataIC50:  112nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed