BDBM6352 2-Aminoquinazoline 31::8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-yl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Pyrido[2,3-d]pyrimidin-7-one 10

SMILES Cc1cc(=O)n(C2CCCC2)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc12

InChI Key InChIKey=LRDLFKVCAQLFQM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 6352   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Naeja Pharmaceutical

LigandPNGBDBM6352(2-Aminoquinazoline 31 | 8-cyclopentyl-5-methyl-2-{...)
Affinity DataIC50: >5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Naeja Pharmaceutical

LigandPNGBDBM6352(2-Aminoquinazoline 31 | 8-cyclopentyl-5-methyl-2-{...)
Affinity DataIC50: >5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Naeja Pharmaceutical

LigandPNGBDBM6352(2-Aminoquinazoline 31 | 8-cyclopentyl-5-methyl-2-{...)
Affinity DataIC50: >5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Naeja Pharmaceutical

LigandPNGBDBM6352(2-Aminoquinazoline 31 | 8-cyclopentyl-5-methyl-2-{...)
Affinity DataIC50: >5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6352(2-Aminoquinazoline 31 | 8-cyclopentyl-5-methyl-2-{...)
Affinity DataIC50:  14nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Naeja Pharmaceutical

LigandPNGBDBM6352(2-Aminoquinazoline 31 | 8-cyclopentyl-5-methyl-2-{...)
Affinity DataIC50: >5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Naeja Pharmaceutical

LigandPNGBDBM6352(2-Aminoquinazoline 31 | 8-cyclopentyl-5-methyl-2-{...)
Affinity DataIC50: >5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6352(2-Aminoquinazoline 31 | 8-cyclopentyl-5-methyl-2-{...)
Affinity DataIC50:  14nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed