BDBM79181 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::10-[3-(4-methylpiperazino)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::MLS001146870::SMR000059133::TRIFLUOPERAZINE::TRIFLUOPERAZINE DIHYDROCHLORIDE::Trifluperazine::US11542290, Compound Trifluoperazine::cid_2913535::cid_5566

SMILES CN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1

InChI Key InChIKey=ZEWQUBUPAILYHI-UHFFFAOYSA-N

Data  71 KI  22 IC50  6 Kd

PDB links: 7 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 99 hits for monomerid = 79181   

TargetATP-dependent translocase ABCB1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 7.20E+3nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKd:  0.532nMAssay Description:Compound was tested for its effect on dopamine saturation analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DNA-PK in human U1810 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlbumin(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to Wistar rat serum albuminMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalmodulin-1(Human)
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to calmodulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalmodulin(Bovine)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to bovine brain CaM by FTPFACE analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalmodulin(Bovine)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to dansylated bovine testes CaM by fluorescence analysis in presence of calcium2+More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysozyme C-1(Rat)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibitory effect of compound on the release of lysozyme in rat neutrophils stimulated with fMLP/CBMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-glucuronidase(Rat)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibitory effect of compound on the release of Beta-glucuronidase in rat neutrophils stimulated with fMLP/CBMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 700nMAssay Description:Inhibitory concentration against hepatitis C virus helicase; range 0.6-0.7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWD repeat-containing protein 48(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 1.09E+4nMAssay Description:TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 6.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetPleiotropic ABC efflux transporter of multiple drugs(Baker's yeast)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 350nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKd:  1.04nMAssay Description:Compound was tested for its effect on 5-hydroxytryptamine 2 receptor saturation analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 16nMAssay Description:Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperoneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C zeta type(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of protein kinase CMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf21 cell membrane vesicles assessed as reduction in ATP-dependent [3H]-tauroc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C zeta type(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 7.36E+4nMAssay Description:Inhibition of rat brain PKCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Chemistry and Technology Prague

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of rabbit skeletal muscle microsomes SERCA1a incubated for 10 mins by enzyme-coupled methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalmodulin-1(Human)
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 1.11E+3nMAssay Description:The competition binding assay was performed in a 384-well plate format and in 20 μl reactions. Serial dilutions (0.001-100 μM) of a test co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCalmodulin-1(Human)
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 1.06E+3nMAssay Description:The competition binding assay was performed in a 384-well plate format and in 20 μl reactions. Serial dilutions (0.001-100 μM) of a test co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCalmodulin-1(Human)
Semmelweis University

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 1.06E+3nMAssay Description:The competition binding assay was performed in a 384-well plate format and in 20 μl reactions. Serial dilutions (0.001-100 μM) of a test co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNADPH oxidase 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 1.70E+4nMAssay Description:Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.190nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.410nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.960nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.960nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDopamine receptor D4(Dog)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  2.60nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  2.63nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDopamine receptor D4(Dog)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
In DepthDetails Article
PubMed
TargetEmopamil-binding protein-like(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to emopamil binding protein (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  3.98nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
In DepthDetails Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  5.20nMAssay Description:The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  7.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  8nMAssay Description:Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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