BDBM8049 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 20::4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine::4-(dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine, 2::[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl]-(4-trifluoromethylphenyl)amine

SMILES Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(cc2)C(F)(F)F)n1

InChI Key InChIKey=MEZFDQUDLQCVNX-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8049   

TargetCyclin-dependent kinase 2(Human)
Cyclacel

LigandPNGBDBM8049(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluorom...)
Affinity DataIC50: 290nMAssay Description:In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8049(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluorom...)
Affinity DataIC50: 290nMAssay Description:In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8049(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluorom...)
Affinity DataKi:  290nM ΔG°:  -9.06kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8049(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluorom...)
Affinity DataKi: >2.00E+4nM ΔG°: >-6.51kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed