BDBM8066 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37::4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1-N-dimethylbenzene-1,4-diamine, 3::4-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1-N-dimethylbenzene-1,4-diamine::N-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl]N,N-dimethylbenzene-1,4-diamine

SMILES CN(C)c1ccc(Nc2nccc(n2)-c2sc(C)nc2C)cc1

InChI Key InChIKey=FGGSNQOBRJVAKL-UHFFFAOYSA-N

Data  9 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 8066   

TargetCyclin-dependent kinase 2(Human)
Cyclacel

LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataIC50: 220nMAssay Description:In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataIC50: 220nMAssay Description:In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  6.90nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  220nM ΔG°:  -9.23kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Cyclacel

LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  251nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  575nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  960nM ΔG°:  -8.34kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  2.52E+3nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  4.01E+3nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed