BDBM82411 CAS_75921-69-6::NDP-MSH

SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O

InChI Key InChIKey=UAHFGYDRQSXQEB-LEBBXHLNSA-N

Data  7 KI  13 IC50  26 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 46 hits for monomerid = 82411   

TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataKi:  0.0231nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataKi:  0.224nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataKi:  0.5nMAssay Description:Binding affinity towards human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataKi:  0.680nMAssay Description:Binding affinity towards human Melanocortin 3 receptor (hMC3R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataKi:  0.950nMAssay Description:Binding affinity towards human melanocortin 4 receptor (hMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataKi:  2.39nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataKi:  3.98nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.5nMAssay Description:Agonist potency for human Melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  1nMAssay Description:Agonist potency towards human Melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.0170nMAssay Description:Evaluated for agonist activity at cloned mammalian Melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.132nMAssay Description:Evaluated for agonist activity at cloned Melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  3.60nMAssay Description:Inhibitory activity against human Melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.0230nMAssay Description:Evaluated for agonist activity at cloned mammalian human MSH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  3.80nMAssay Description:Inhibitory activity against Melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  0.860nMAssay Description:Inhibitory concentration against human Melanocortin 5 receptor (hMC5R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.720nMAssay Description:Effective concentration for intracellular cAMP accumulation in L-cells expressing Melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.510nMAssay Description:Binding affinity towards human Melanocortin 3 receptor (hMC3R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.580nMAssay Description:Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.190nMAssay Description:Effective concentration for intracellular cAMP accumulation in L-cells expressing Melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  0.510nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory concentration against human Melanocortin 4 receptor (hMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  4.10nMAssay Description:Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  0.510nMAssay Description:Displacement of [125I]NDP-MSH from Melanocortin 1 receptor at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.190nMAssay Description:effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.580nMAssay Description:effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  0.860nMAssay Description:Displacement of [125I]NDP-MSH from Melanocortin 5 receptor at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]NDP-MSH from Melanocortin 4 receptor at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  4.10nMAssay Description:effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.720nMAssay Description:effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.00500nMAssay Description:Decrease in frog skin reflectivity (melanotropic activity).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human Melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  1nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.0200nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.800nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.0700nMAssay Description:Binding affinity towards human melanocortin 4 receptor (hMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.360nMAssay Description:In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
University Of Florida

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  120nMAssay Description:Agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Mus musculus)
University Of Florida

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  12nMAssay Description:Agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Mus musculus)
University Of Florida

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  75nMAssay Description:Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Mus musculus (Mouse))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  170nMAssay Description:Agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity against human melanocortin receptor hMC1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Cincinnati

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataEC50:  1nMAssay Description:Agonist activity against human melanocortin receptor hMC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Uppsala

Curated by PDSP Ki Database
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed