BDBM86248 CAS_364-98-7::NSC_3019::diazoxide

SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1

InChI Key InChIKey=GDLBFKVLRPITMI-UHFFFAOYSA-N

Data  2 KI  4 IC50  1 Kd  6 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 86248   

LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  3.10E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  8.80E+3nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  8.80E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  3.30E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  2.35E+4nMAssay Description:Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  3.30E+4nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed