BDBM90787 1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride::GUVACINE::Guvacine hydrochloride::MLS000859975::SMR000326834::cid_11957555
SMILES OC(=O)C1=CCCNC1
InChI Key InChIKey=QTDZOWFRBNTPQR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 90787
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-University M£Nchen
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Ludwig-Maximilians-University M£Nchen
Curated by ChEMBL
Ludwig-Maximilians-University M£Nchen
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of mouse GAT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.77E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 2.59E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 2.66E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.68E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 2.79E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
Affinity DataIC50: 1.68E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
Affinity DataIC50: 2.59E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 2.77E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.68E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
Affinity DataIC50: 2.66E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich
Curated by ChEMBL
Ludwig Maximilians University At Munich
Curated by ChEMBL
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair